3D-printing of solid lipid tablets from emulsion gels

Interest in 3D-printing technologies for pharmaceutical manufacturing of oral dosage forms is driven by the need personalized medicines. Most research to date has focused on printing polymeric-based drug delivery systems at high temperatures. Furthermore, formulation development continuously challenged large number poorly water-soluble drugs, which require more advanced enabling formulations improve bioavailability. In this work, we used semi-solid extrusion (SSE) emulsion gels with three types emulsified lipid-based (LBFs) produce solid lipid tablets incorporating drug, fenofibrate. Tablets were successfully 3D-printed from using SSE room temperature, making methodology particularly useful thermolabile compounds. The well-defined mass and disintegrated rapidly (<15 min). Importantly, oil droplet size reconstituted after dispersion subsequent digestion was similar traditional liquid LBFs. This work demonstrates successful use fabricating based gels. method further promising demand production forms, necessary flexible adjustment e.g., pediatric patients, when compounds constitute core therapy.